Patients living with severe knee osteoarthritis often feel they have reached the end of the road.
They may have already tried physiotherapy, exercise programmes, pain medication, steroid injections or hyaluronic acid injections. Many have been told that a total knee replacement is the next step, yet face lengthy waiting lists or are not ready to undergo major surgery.

At Pro Sports Medicine, we are pleased to introduce KioMedine, an innovative new injection treatment for severe knee osteoarthritis that offers an exciting non-surgical option for suitable patients across Cardiff, South Wales and the South West.
Knee osteoarthritis is one of the most common causes of pain and disability in adults.
As the condition progresses, patients often experience:
For many patients, symptoms continue to worsen despite conservative treatment.
While knee replacement surgery can be highly successful, not everyone is ready for surgery, and some patients may be unsuitable due to age, medical conditions or personal preference.
This has created a growing demand for effective treatments that can help bridge the gap between conservative management and surgery.
KioMedine is a new generation injectable fluid implant developed specifically for the treatment of symptomatic knee osteoarthritis.
Unlike traditional viscosupplement injections, KioMedine contains a unique molecule called Carboxymethyl-Chitosan (CM-Chitosan), derived from button mushrooms through a highly refined manufacturing process.
The technology was developed in Belgium and represents an entirely new class of osteoarthritis treatment.
KioMedine is administered through a single injection directly into the knee joint and is designed to improve joint function, reduce pain and enhance quality of life.
One of the most interesting aspects of KioMedine is its dual mechanism of action.

Healthy joints rely on smooth movement and low friction between cartilage surfaces.
KioMedine enhances joint lubrication, helping to improve movement and reduce symptoms associated with everyday activities such as walking, climbing stairs and exercise.
Research suggests that oxidative stress plays an important role in the progression of osteoarthritis.
KioMedine contains antioxidant properties that help neutralise harmful free radicals within the joint environment, potentially protecting the body’s natural joint structures.
This combination of lubrication and joint protection makes KioMedine different from many traditional injection therapies.
One of the most exciting findings from recent clinical research is the potential for KioMedine to help patients postpone knee replacement surgery.
Clinical studies have demonstrated significant improvements in pain and function in patients with advanced knee osteoarthritis, including those who would otherwise have been considered candidates for total knee replacement.
For patients facing lengthy NHS waiting lists, this may provide an important opportunity to maintain mobility, remain active and improve quality of life whilst delaying surgery.
KioMedine may be suitable for patients who:

A specialist assessment is required to determine whether KioMedine is appropriate for your individual condition.
At Pro Sports Medicine, every patient undergoes a comprehensive assessment before treatment recommendations are made.
Our team combines:
KioMedine forms part of our comprehensive Knee Osteoarthritis Clinic and Regenerative Medicine Service, allowing patients access to the latest evidence-informed treatments available in Wales.
Most patients can return home immediately after treatment.
We typically recommend:
Our clinicians will provide individualised guidance following treatment.
If you have been diagnosed with knee osteoarthritis and are looking for alternatives to surgery, KioMedine may be worth considering.
Our team can assess your symptoms, review previous treatments and discuss whether this innovative new injection could help you stay active for longer.
To learn more about KioMedine and whether it may be suitable for your knee pain, contact Pro Sports Medicine today.
Our specialist clinicians are proud to be among the first providers in Wales offering this innovative treatment for severe knee osteoarthritis.